The Pyke Syndicate, also known as the Pyke Family, or simply as the Pykes, was a spice dealership within the Spice Cartel that operated in the criminal underworld from their homeworld of Oba Diah. They also participated in the crime raids on Mandalore to start the Death Watch rule on said planet.

The Pyke Syndicate almost completely controlled the production of raw spice in the galaxy. The Pykes struggled to maintain a relationship with the Black Sun, even when they both joined Maul‘s Shadow Collective. They subsequently abandoned the Shadow Collective when it became more costly than profitable for them and when they were under attack. However, they later rejoined the Collective, though Maul reminded them that the Pyke Syndicate was a small player in his operations and could be replaced. After the fall of the Galactic Republic, Maul eventually became the shadowy spearhead of Crimson Dawn, another of the five most powerful criminal organizations. The Pykes later maintained a shaky alliance with Crimson Dawn.