The following events took place in the year 22 BBY, also known as 3255 LY according to the Lothal Calendar and year 7955 in the C.R.C. calendar.

• The Antar 4 schism occurs over whether to support the Galactic Republic or the Confederacy of Independent Systems.
• A border dispute occurs on Ansion.
• Zam Wesell and Jango Fett attempt to assassinate Senator Padmé Amidala on Coruscant.
• The Separatist Crisis ends and the Clone Wars begin with the First Battle of Geonosis.
• Anakin Skywalker and Padmé Amidala are married in a secret ceremony on Naboo.
• Anakin Skywalker is promoted to Jedi Knight.
• Concurrent to the early period of the Clone Wars, RA-7 protocol droids are created with plating from the 3PO-series protocol droid. One of the droids made during this time is 4-A7, who is actually assembled by Separatist allies within Arakyd Industries.
• The Battle of Muunilinst occurs; the Republic defeats the Separatist stronghold, although the victory comes at great cost, as Muun cities were heavily damaged in the battle, and the engagement will lead the galaxy to face a financial crisis.
• Mace Windu and his Jedi squad battles with the Separatists and the hired droid mercenary AD-W4 over the planet Hissrich.
• Anakin Skywalker destroys Admiral Trench’s flagship above the Battle of Christophsis and delivers needed supplies to senator Bail Organa on the ground.
• Ahsoka Tano is assigned to Anakin Skywalker as his Padawan learner.
• Anakin Skywalker and Ahsoka Tano rescue Jabba’s son Rotta from Asajj Ventress.
• Ziro the Hutt is imprisoned after Padmé Amidala exposes his role in the plot to kidnap Rotta.
• General Grievous takes the warship Malevolence as his flagship and launches a campaign in which he brought about the destruction of multiple Republic fleets. The ship is later destroyed by Republic and Jedi forces.
• The planet Rodia rejoins the Republic after a successful mission by Senator Padmé Amidala, Representative Jar Jar Binks, and protocol droid C-3PO.